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During World War I, Abie Levy, a soldier in the A.E.F., is wounded in combat.  While recovering in a hospital, he meets Rosemary Murphy, an entertainer.  They fall in love, return to the United States, and get married in an Episcopal church in Jersey City.  Abie takes Rosemary to his home and introduces her as his sweetheart, Rosie Murpheski; they are then married by a rabbi.  Mr.  Murphy arrives with a priest and, amid discord and discontent, the young people are married again, this time by the priest.

Disowned by both families, Rosemary and Abie are befriended only by the Cohens.  On Christmas Eve, the Cohens and their rabbi persuade Solomon to see his son and his new grandchildren; the priest urges Mr. Murphy to do the same.  This surprise visit begins in acrimony, but ends peacefully as Rosemary presents her newborn twins: Patrick Joseph, named for her father, and Rebecca, named for Abie's dead mother.